[Phosphodiesterase inhibitors]

Ann Cardiol Angeiol (Paris). 1990 Sep;39(7):427-31.
[Article in French]

Abstract

Phosphodiesterase III inhibitors constitute a new therapeutic group for congestive cardiac failure. They inhibit the degradation of cyclic adenosine monophosphate and increase the intracellular calcium. They have a double inotropic and vasodilator haemodynamics occurs without any increase in the myocardial effect. The improvement in the consumption of oxygen. The beneficial haemodynamic effect seems to last over a medium period of time, but the survival in the long term treatment is not yet known.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Electrophysiology
  • Heart Failure / drug therapy*
  • Humans
  • Kidney / drug effects
  • Oxygen Consumption / drug effects
  • Phosphodiesterase Inhibitors / pharmacology*
  • Phosphodiesterase Inhibitors / therapeutic use

Substances

  • Phosphodiesterase Inhibitors