Abstract
Phytochemical investigation of the aerial parts of Inula hupehensis Ling. led to the isolation and identification of 27 sesquiterpene lactones (1-27), including three new eudesmanolides (3-5), three new germacranolides (9-11), one new xanthanolide (16), two new carabrone derivatives (25-26), and 18 known sesquiterpene lactones. The structures were elucidated by extensive spectroscopic methods and comparison to previously reported spectroscopic data. All compounds were evaluated for their inhibitory effects against LPS-induced nitric oxide production in RAW264.7 macrophages, and compound 5 showed the strongest activity with the IC₅₀ value of 3.2 ± 0.4 µM.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cell Line
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Cell Survival / drug effects
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Inhibitory Concentration 50
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Inula / chemistry*
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology*
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Lipopolysaccharides / adverse effects
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Macrophages / chemistry
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Macrophages / drug effects*
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / chemistry
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Plant Components, Aerial / chemistry
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Sesquiterpenes, Germacrane / chemistry
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Sesquiterpenes, Germacrane / isolation & purification
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Sesquiterpenes, Germacrane / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lactones
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Lipopolysaccharides
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Sesquiterpenes
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Sesquiterpenes, Germacrane
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eudesmanolide
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germacranolide
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Nitric Oxide