Abstract
Superfamily 2 helicases are involved in all aspects of RNA metabolism, and many steps in DNA metabolism. This review focuses on the basic mechanistic, structural and biological properties of each of the families of helicases within superfamily 2. There are ten separate families of helicases within superfamily 2, each playing specific roles in nucleic acid metabolism. The mechanisms of action are diverse, as well as the effect on the nucleic acid. Some families translocate on single-stranded nucleic acid and unwind duplexes, some unwind double-stranded nucleic acids without translocation, and some translocate on double-stranded or single-stranded nucleic acids without unwinding.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Amino Acid Motifs
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Amino Acid Sequence
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Animals
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DEAD-box RNA Helicases / classification
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DEAD-box RNA Helicases / genetics
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DEAD-box RNA Helicases / metabolism
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DNA Helicases / classification
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DNA Helicases / genetics
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DNA Helicases / metabolism*
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Enzyme Stability
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Humans
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Models, Biological
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Models, Molecular
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Protein Conformation
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RNA Helicases / classification
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RNA Helicases / genetics
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RNA Helicases / metabolism*
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RNA Viruses / enzymology
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RNA Viruses / genetics
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RecQ Helicases / classification
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RecQ Helicases / genetics
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RecQ Helicases / metabolism
Substances
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DNA Helicases
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RecQ Helicases
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DEAD-box RNA Helicases
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RNA Helicases