Abstract
Obesity has become a global health issue because of its increased morbidity and mortality, and a close association with at least 20 different cancers. Clinical and epidemiological studies have suggested that obesity and overweight are positively related with the risk of GBC. Gallbladder cancer (GBC) is a relatively infrequent but highly lethal neoplasm. Obesity may disturb lipid and endogenous hormones metabolism, affect gallbladder motility, increase the risk of gallstones, and thus plays a role in GBC. Control of obesity through measures such as lifestyle modification, healthy diet, and regular exercise may prove useful in the prevention of GBC.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adipokines / metabolism
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Adipose Tissue / metabolism
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Adipose Tissue / pathology
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Animals
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Female
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Gallbladder / pathology
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Gallbladder Neoplasms / epidemiology
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Gallbladder Neoplasms / etiology*
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Gallbladder Neoplasms / metabolism
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Gallbladder Neoplasms / prevention & control
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Gallstones / complications
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Gonadal Steroid Hormones / metabolism
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Humans
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Hyperinsulinism / complications
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Insulin Resistance
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Life Style
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Lipid Metabolism
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Male
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Models, Biological
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Obesity / complications*
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Obesity / epidemiology
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Obesity / metabolism
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Risk Factors
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Somatomedins / metabolism
Substances
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Adipokines
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Gonadal Steroid Hormones
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Somatomedins