Assignment of the gene for central core disease to chromosome 19

Hum Genet. 1990 Dec;86(2):187-90. doi: 10.1007/BF00197703.

Abstract

In a large kindred in which the gene for central core disease is segregating, we have demonstrated linkage between the disorder and a marker on chromosome 19q. Marker D19S9 (p1J2) was linked to central core disease with a lod score of 6.4 at theta = 0.03 (support interval 0.01-0.14) thus localizing the gene for this disorder in or very close to 19q12-q13.2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Chromosomes, Human, Pair 19*
  • Female
  • Genes, Dominant
  • Genetic Linkage*
  • Genetic Markers
  • Humans
  • Lod Score
  • Male
  • Middle Aged
  • Muscular Diseases / genetics*
  • Pedigree
  • Restriction Mapping

Substances

  • Genetic Markers