The objective of medical investigations during and after the 366-day manned mission was to accumulate information about human responses to long-term effects of microgravity. To do this, cardiovascular and other systems were examined in detail during and after exposure. The results gave evidence that the crewmembers well adapted to the long-term flight effects. Their good health condition and high work capacity were supported by adequate medical procedures. Postflight readaptation developed similarly to what was seen after previous flights of shorter duration (6-11 months). No qualitatively new changes in the physiological systems were detected during or after this mission.