Comparison of outcomes after typical and atypical eclampsia: a retrospective study

J Matern Fetal Neonatal Med. 2012 Nov;25(11):2419-23. doi: 10.3109/14767058.2012.699117. Epub 2012 Jun 29.

Abstract

Objective: To evaluate the characteristics, clinical features and maternal-perinatal outcomes after atypical eclampsia.

Methods: In a retrospective study, we compared demographics, clinical characteristics and outcomes between typical and atypical eclampsia.

Results: Of 90 eclamptic patients, 56 had typical eclamptic features and 34 had atypical features. Compared to typical eclampsia, atypical eclampsia had higher gestational age (37.6 ± 3.3 vs. 34.6 ± 4.2 weeks, p = 0.001), a higher incidence of no antenatal risk factors [25 (73.5%) vs. 12 (21.4%), p < 0.001], less antepartum seizures [11 (32.4%) vs. 45 (80.4%), p < 0.001], a lower incidence of prodromal symptoms [20 (58.5%) vs. 49 (87.5%), p = 0.002], and a higher incidence of no lesion in brain imaging [16 (47.1%) vs. 12 (21.4%), p = 0.010). Although atypical eclampsia was associated with a lower odd ratio (OR) in composite perinatal complications (OR = 0.22, 95% CI = 0.08-0.60, p = 0.003), composite maternal complications did not differ between the two groups (OR = 0.52, 95% CI = 0.08-0.60, p =0.191).

Conclusions: Maternal outcomes did not differ between the two groups. Therefore, more attention should be focused on atypical eclampsia.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adult
  • Cesarean Section / statistics & numerical data
  • Eclampsia / classification
  • Eclampsia / epidemiology*
  • Eclampsia / etiology
  • Eclampsia / mortality
  • Female
  • Humans
  • Infant Mortality
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Outcome / epidemiology*
  • Prodromal Symptoms
  • Retrospective Studies
  • Risk Factors
  • Seizures / epidemiology
  • Young Adult