Spatial and temporal properties of eye movements produced by electrical stimulation of semicircular canal afferents

J Neurophysiol. 2012 Sep;108(5):1511-20. doi: 10.1152/jn.01029.2011. Epub 2012 Jun 6.

Abstract

To investigate the characteristics of eye movements produced by electrical stimulation of semicircular canal afferents, we studied the spatial and temporal features of eye movements elicited by short-term lateral canal stimulation in two squirrel monkeys with plugged lateral canals, with the head upright or statically tilted in the roll plane. The electrically induced vestibuloocular reflex (eVOR) evoked with the head upright decayed more quickly than the stimulation signal provided by the electrode, demonstrating an absence of the classic velocity storage effect that improves the dynamics of the low-frequency VOR. When stimulation was provided with the head tilted in roll, however, the eVOR decayed more rapidly than when the head was upright, and a cross-coupled vertical response developed that shifted the eye's rotational axis toward alignment with gravity. These results demonstrate that rotational information provided by electrical stimulation of canal afferents interacts with otolith inputs (or other graviceptive cues) in a qualitatively normal manner, a process that is thought to be mediated by the velocity storage network. The observed interaction between the eVOR and graviceptive cues is of critical importance for the development of a functionally useful vestibular prosthesis. Furthermore, the presence of gravity-dependent effects (dumping, spatial orientation) despite an absence of low-frequency augmentation of the eVOR has not been previously described in any experimental preparation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Afferent Pathways / physiology
  • Animals
  • Biophysics
  • Electric Stimulation
  • Eye Movements / physiology*
  • Functional Laterality
  • Head Movements / physiology
  • Larynx, Artificial
  • Reflex, Vestibulo-Ocular / physiology*
  • Saimiri
  • Semicircular Canals / physiology*
  • Space Perception / physiology*
  • Time Factors