RETRACTED: Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice

Gastroenterology. 2012 Sep;143(3):741-753.e4. doi: 10.1053/j.gastro.2012.05.045. Epub 2012 Jun 4.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief and Deputy Editor-in-Chief following an investigation into the data that were presented in several figures within the article. A number of images used in this article are believed to be duplicated images. The authors stated that they inadvertently inserted images of the wrong blots in several of the figures, resulting in the duplications; however, they did not address all of the concerns raised. Because the editors were no longer confident in the conclusions of the article based on these incorrect data, a decision was made to retract the paper. All authors have been notified of this decision. The University of Campinas (UNICAMP) in São Paulo, Brazil was contacted regarding these concerns, but to date the journal has received no response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Animals
  • Antibodies, Monoclonal / pharmacology
  • Antineoplastic Agents / pharmacology
  • Apoptosis
  • Azoxymethane
  • Blotting, Western
  • Cell Proliferation
  • Colitis / etiology*
  • Colitis / genetics
  • Colitis / immunology
  • Colitis / metabolism
  • Colitis / pathology
  • Colitis / prevention & control
  • Colon / drug effects
  • Colon / immunology*
  • Colon / metabolism
  • Colonic Neoplasms / etiology*
  • Colonic Neoplasms / genetics
  • Colonic Neoplasms / immunology
  • Colonic Neoplasms / metabolism
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / prevention & control
  • Dextran Sulfate
  • Disease Models, Animal
  • Enzyme Activation
  • HT29 Cells
  • Humans
  • Hyperinsulinism / drug therapy
  • Hyperinsulinism / etiology
  • Hyperinsulinism / metabolism
  • Hypoglycemic Agents / pharmacology
  • I-kappa B Kinase / metabolism
  • Immunohistochemistry
  • Inflammation Mediators / antagonists & inhibitors
  • Inflammation Mediators / metabolism*
  • Infliximab
  • Insulin / metabolism
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, SCID
  • Obesity / complications*
  • Obesity / genetics
  • Obesity / immunology
  • Obesity / metabolism
  • Phosphatidylinositol 3-Kinase
  • Pioglitazone
  • Proto-Oncogene Proteins c-akt / metabolism
  • Signal Transduction
  • TOR Serine-Threonine Kinases / metabolism
  • Thiazolidinediones / pharmacology
  • Time Factors
  • Tumor Burden
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / metabolism*
  • Up-Regulation
  • Xenograft Model Antitumor Assays

Substances

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Hypoglycemic Agents
  • Inflammation Mediators
  • Insulin
  • Thiazolidinediones
  • Tumor Necrosis Factor-alpha
  • Dextran Sulfate
  • Infliximab
  • mTOR protein, mouse
  • Phosphatidylinositol 3-Kinase
  • Proto-Oncogene Proteins c-akt
  • TOR Serine-Threonine Kinases
  • I-kappa B Kinase
  • JNK Mitogen-Activated Protein Kinases
  • Azoxymethane
  • Pioglitazone