Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp

Yunjiang Feng; Rohan A Davis; Melissa L Sykes; Vicky M Avery; Ronald J Quinn

doi:10.1016/j.bmcl.2012.05.029

Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4873-6. doi: 10.1016/j.bmcl.2012.05.029. Epub 2012 May 17.

Authors

Yunjiang Feng¹, Rohan A Davis, Melissa L Sykes, Vicky M Avery, Ronald J Quinn

Affiliation

¹ Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.

PMID: 22677313
DOI: 10.1016/j.bmcl.2012.05.029

Abstract

Bioassay-guided isolation of the CH(2)Cl(2)/MeOH extract from the Australian sponge Iotrochota sp. resulted in the purification of two new N-cinnamoyl-amino acids, iotrochamides A (1) and B (2). The chemical structures of 1 and 2 were determined by 1D/2D NMR and MS data analyses. Compounds 1 and 2 were shown to inhibit Trypanosoma brucei brucei with IC(50) values of 3.4 and 4.7 μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemistry*
Antimalarials / isolation & purification
Antimalarials / pharmacology
Ceramides / chemistry*
Ceramides / isolation & purification
Ceramides / pharmacology
HEK293 Cells
Humans
Molecular Structure
Porifera / chemistry*
Structure-Activity Relationship
Trypanosoma brucei brucei / drug effects*

Substances

Antimalarials
Ceramides
iotrochotamide I
iotrochotamide II