Cancer-associated fibroblasts (CAFs) is fibroblast cells activated by cancer cells in tumor with myofibroblasts cells (MFs) properties. CAFs is the main components of the tumor microenvironment. Malignant conversion of CAFs phenotype is closely related to the tumor evolution. In this review, we summarized that: (1) The source of CAFs and morphology, and the relation between heterogenicity and the malignant phenotype conversion of CAFs with time-space change; (2) The current research status and question of clinical application on CAFs; (3) The relation of CAFs and invasion and metastasis of lung cancer; (4) CAFs in the prognosis and treatment of lung cancer.
癌相关成纤维细胞（cancer-associated fibroblasts, CAFs）是肿瘤组织中被癌细胞激活的成纤维细胞，具有成肌纤维细胞的特性。CAFs表型恶性转换与肿瘤演进密切相关，同时CAFs是肿瘤微环境的主要组织成分。本文主要从以下方面结合肺癌进行综述：①CAFs的来源及其形态学特征，CAFs异质性及其表型时、空转换的临床意义；②CAFs的研究现状及临床应用中的问题；③CAFs与肺癌侵袭与转移的关系；④CAFs对肺癌预后及其治疗的影响。