Molecular engineered super-nanodevices: smart and safe delivery of potent drugs into tumors

Adv Mater. 2012 Jul 17;24(27):3639-45. doi: 10.1002/adma.201200954. Epub 2012 Jun 12.

Abstract

A super-nanodevice engineered at molecular level integrates various desired properties in a smart and coordinated way, and can "switch on" or "turn off" certain functionalities as required. Importantly, it can break through complex physiological barriers, and then precisely ferry potent toxic triptolide into tumor cells in vivo, thus significantly maximizing the therapeutic efficacy and reducing the drug toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents / administration & dosage*
  • Cell Line, Tumor
  • Cetuximab
  • Chemistry, Pharmaceutical
  • Drug Carriers / chemistry*
  • Glutathione / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Mice
  • Nanotechnology*
  • Neoplasms / drug therapy*
  • Polyesters / chemistry
  • Polyethylene Glycols / chemistry
  • Transplantation, Heterologous

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • Drug Carriers
  • Polyesters
  • polycaprolactone
  • Polyethylene Glycols
  • Glutathione
  • Cetuximab