Abstract
A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC(50) value of 11 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimalarials / blood
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Equatorial Guinea
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Humans
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Hypocreales / chemistry*
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Inhibitory Concentration 50
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Molecular Structure
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Naphthalenes / blood
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Parasitic Sensitivity Tests
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Plant Leaves / microbiology
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Plasmodium falciparum / drug effects
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Pyrones / blood
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / pharmacology
Substances
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Antimalarials
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Naphthalenes
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Pyrones
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lasionectrin