Primary effusion lymphoma with central nervous system involvement in an HIV-negative homosexual male

Oluyomi E Kabiawu-Ajise; Jonathan Harris; Naima Ismaili; Edward Amorosi; Sherif Ibrahim

doi:10.1159/000338183

Primary effusion lymphoma with central nervous system involvement in an HIV-negative homosexual male

Acta Haematol. 2012;128(2):77-82. doi: 10.1159/000338183. Epub 2012 Jun 13.

Authors

Oluyomi E Kabiawu-Ajise¹, Jonathan Harris, Naima Ismaili, Edward Amorosi, Sherif Ibrahim

Affiliation

¹ New York University Langone Medical Center, New York, NY 10016, USA.

PMID: 22699313
DOI: 10.1159/000338183

Abstract

Primary effusion lymphoma (PEL) is a rare form of non-Hodgkin lymphoma that presents with body cavity effusions. It occurs chiefly in immunodeficient HIV-positive patients. The tumor cells generally express gene sequences of human herpesvirus-8 (HHV-8) and Epstein-Barr virus (EBV). Tumor cells of HIV-negative patients usually express HHV-8 gene sequences, but rarely those of EBV. We report a novel case of PEL in an HIV-negative homosexual male whose tumor cells expressed both HHV-8 and EBV gene sequences and who developed evidence of central nervous system involvement.

Publication types

Case Reports

MeSH terms

Aged
Central Nervous System Diseases / pathology*
HIV Seronegativity*
Homosexuality, Male*
Humans
Immunophenotyping
Lymphoma, Primary Effusion / pathology*
Male