Abstract
11 patients experienced 40 intrathecal injections of cytotoxic drugs during the treatment of acute leukemia. Tiapride was used as a preventive or curative therapy for headache. Results were found excellent or good in 70% of cases. Frequency and intensity of headache were reduced by half. Tiapride seems more effective in early headache than in cephalalgia occuring later.
MeSH terms
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Adult
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Aged
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Antimetabolites, Antineoplastic / administration & dosage*
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Benzamides / therapeutic use*
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Cytarabine / administration & dosage
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Cytarabine / adverse effects
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Female
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Headache / drug therapy*
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Headache / etiology
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Headache / prevention & control
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Humans
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Injections, Spinal
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Leukemia / drug therapy*
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Male
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Meningeal Neoplasms / drug therapy
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Methotrexate / administration & dosage
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Methotrexate / adverse effects
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Middle Aged
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Tiapamil Hydrochloride / therapeutic use*
Substances
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Antimetabolites, Antineoplastic
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Benzamides
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Cytarabine
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Tiapamil Hydrochloride
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Methotrexate