The importance of preclinical trial timing - a potential reason for the disconnect between mouse studies and human clinical trials in ALS

MeSH terms

• Amyotrophic Lateral Sclerosis / drug therapy*
• Amyotrophic Lateral Sclerosis / pathology
• Animals
• Anti-Bacterial Agents / administration & dosage*
• Antioxidants / administration & dosage
• Ceftriaxone / administration & dosage*
• Disease Models, Animal
• Disease Progression
• Drug Evaluation, Preclinical / methods*
• Drug Therapy, Combination
• Humans
• Mice
• Mice, Transgenic
• Minocycline / administration & dosage*
• Research Design
• Superoxide Dismutase
• Treatment Outcome
• Vitamin E / administration & dosage