Aim: To investigate the reliability of massive hepatectomy models by using clip techniques.
Methods: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.
Results: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques.
Conclusion: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.
Keywords: Animal model; Clip; Hepatectomy; Microsurgery; Surgical technique.