Cross-talk within the tumor microenvironment mediates Th2-type inflammation in pancreatic cancer

Oncoimmunology. 2012 Jan 1;1(1):89-91. doi: 10.4161/onci.1.1.17939.

Abstract

Th2-type inflammation has been proposed to facilitate tumor growth. In De Monte et al. (J Exp Med 208:469-478, 2011) we identify in pancreatic cancer a complex cytokine/chemokine cross-talk within the tumor microenvironment mediating Th2 immune-deviation and show that the ratio of Th2/Th1 tumor infiltrating lymphocytes is an independent predictive marker of patients survival.