Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: design, synthesis and biological evaluation

Eur J Med Chem. 2012 Aug:54:549-56. doi: 10.1016/j.ejmech.2012.06.001. Epub 2012 Jun 12.

Abstract

A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by (1)H NMR, (13)C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Diamide / chemical synthesis
  • Diamide / chemistry*
  • Diamide / pharmacology*
  • Drug Design*
  • Humans
  • Inhibitory Concentration 50
  • Isoxazoles / chemistry*
  • ortho-Aminobenzoates / chemistry*

Substances

  • Antineoplastic Agents
  • Isoxazoles
  • ortho-Aminobenzoates
  • anthranilic acid
  • Diamide