Abstract
A 39-year-old man presented a CD4 T cell count of 78/µL and HIV-RNA at 6.6 × 10(5) copies/mL at his first medical examination. After the 58th day, we initiated HBV-active antiretroviral therapy. Three months after the start of antiretroviral therapy, he was diagnosed with hepatic flare on the basis of elevated AST and ALT levels without detecting HBV-DNA. Although after continuing the medication his AST and ALT levels increased to 700 IU/L and 1,400 IU/L, respectively, he showed improvement following a natural course and was discharged from hospital after the 169th day. This is a case of hepatic flare likely caused by immune reconstitution associated with resolved HBV infection.
MeSH terms
-
Adult
-
Alanine Transaminase / blood
-
Anti-HIV Agents / therapeutic use
-
Antiviral Agents / adverse effects*
-
Aspartate Aminotransferases / blood
-
CD4 Lymphocyte Count
-
HIV Infections / complications*
-
HIV Infections / immunology
-
HIV Infections / virology
-
Hepatitis B / complications*
-
Hepatitis B / drug therapy*
-
Hepatitis B / immunology
-
Hepatitis B / virology
-
Hepatitis B virus / genetics
-
Hepatitis B virus / isolation & purification
-
Humans
-
Immune Reconstitution Inflammatory Syndrome / etiology
-
Immune Reconstitution Inflammatory Syndrome / immunology
-
Immune Reconstitution Inflammatory Syndrome / virology
-
Male
-
RNA, Viral / blood
-
Viral Load
Substances
-
Anti-HIV Agents
-
Antiviral Agents
-
RNA, Viral
-
Aspartate Aminotransferases
-
Alanine Transaminase