Selectivity enhancement arising from interactions at the PI3K unique pocket

ChemMedChem. 2012 Aug;7(8):1379-83. doi: 10.1002/cmdc.201200245. Epub 2012 Jun 22.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Cell Proliferation / drug effects
  • Computer Simulation
  • Cyclin-Dependent Kinase 2 / antagonists & inhibitors
  • Cyclin-Dependent Kinase 2 / metabolism
  • Humans
  • MCF-7 Cells
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Kinase Inhibitors / chemical synthesis
  • Protein Kinase Inhibitors / chemistry
  • Protein Kinase Inhibitors / pharmacology
  • Protein Structure, Tertiary
  • Pyridines / chemical synthesis
  • Pyridines / chemistry
  • Pyridines / pharmacology

Substances

  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Kinase Inhibitors
  • Pyridines
  • Cyclin-Dependent Kinase 2
  • pyridine