EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms

Leukemia. 2012 Dec;26(12):2557-60. doi: 10.1038/leu.2012.146. Epub 2012 Jun 1.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Base Sequence
  • Enhancer of Zeste Homolog 2 Protein
  • Female
  • Gene Expression Regulation*
  • Histones / metabolism
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Mutation / genetics*
  • Myelodysplastic Syndromes / genetics
  • Myelodysplastic Syndromes / metabolism*
  • Myelodysplastic Syndromes / pathology
  • Myeloproliferative Disorders / genetics
  • Myeloproliferative Disorders / metabolism*
  • Myeloproliferative Disorders / pathology
  • Polycomb Repressive Complex 2 / chemistry
  • Polycomb Repressive Complex 2 / genetics
  • Polycomb Repressive Complex 2 / metabolism*
  • Prognosis
  • Protein Conformation
  • Sequence Homology, Amino Acid

Substances

  • EED protein, human
  • Histones
  • EZH2 protein, human
  • Enhancer of Zeste Homolog 2 Protein
  • Polycomb Repressive Complex 2