Background: Based on beneficial reports of pamidronate use for reflex sympathetic dystrophy in reduction of pain and swelling, this drug can be studied as a novel treatment for refractory lymphedema. This study aims to determine the effectiveness of pamidronate on lymphedema and its possible side effects.
Methods: Twelve cases of lower limb refractory lymphedema were enrolled. They received intravenous pamidronate monthly for 3 consecutive months and were followed by measuring any discomfort with visual analog scale (VAS) and physician global assessment, based on objective signs of limb volume and circumference.
Results: The limb volume, circumference, and satisfaction of the patients improved significantly.
Conclusion: Pamidronate when is added to conservative treatments may reduce lymphedema and improve the patient's comfort.
Keywords: Bisphosphonate; Pamidronate; Refractory lymphedema.