Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development

Tetyana Yevsa; Tae-Won Kang; Lars Zender

doi:10.4161/onci.19128

Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development

Oncoimmunology. 2012 May 1;1(3):398-399. doi: 10.4161/onci.19128.

Authors

Tetyana Yevsa¹, Tae-Won Kang, Lars Zender

Affiliation

¹ Helmholtz Centre for Infection Research; Braunschweig, Germany ; Hannover Medical School; Department of Gastroenterology, Hepatology and Endocrinology; Hannover, Germany.

Abstract

Here we discuss a recently published study from our group on how a continuous CD4 T-cell dependent immune clearance of premalignant senescent cells, designated "senescence surveillance," restricts liver cancer development.