Abstract
β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells.
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects*
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Caulerpa / chemistry*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Chromatin / drug effects
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Dose-Response Relationship, Drug
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Female
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Humans
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Oligosaccharides / isolation & purification
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Oligosaccharides / pharmacology*
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Plant Extracts / chemistry*
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Poly(ADP-ribose) Polymerase Inhibitors
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Protein Denaturation
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Sodium Hydroxide / chemistry
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Sulfuric Acids / chemistry
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Xylans / isolation & purification
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Xylans / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Chromatin
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Oligosaccharides
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Plant Extracts
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Poly(ADP-ribose) Polymerase Inhibitors
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Sulfuric Acids
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Xylans
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Sodium Hydroxide
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1,3-xylan
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sulfuric acid