Abstract
The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Conserved Sequence
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Host-Pathogen Interactions / immunology
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Humans
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Immunity, Innate
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Interferon Type I / metabolism
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Lyssavirus / classification
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Lyssavirus / genetics*
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Lyssavirus / immunology*
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Lyssavirus / pathogenicity
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Molecular Sequence Data
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Rabies virus / genetics
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Rabies virus / immunology
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Rabies virus / pathogenicity
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STAT Transcription Factors / immunology
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Sequence Homology, Amino Acid
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Signal Transduction / immunology
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Species Specificity
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Viral Proteins / genetics
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Viral Proteins / immunology
Substances
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Interferon Type I
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STAT Transcription Factors
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Viral Proteins