The evolution of salivary diagnostics has reached a new level toward the goal of using saliva as a powerful fluid for early detection and the first line of diagnosis for life-threatening diseases such as cancer, metabolic disorders, infections, and inflammatory diseases. Newly developed tools such as the novel saliva-based POCT and the SKB are helping to realize the goal of making salivary diagnostics available to clinicians worldwide. This is a unique moment where dentistry may be paving a new path for primary healthcare.