Occurrence and molecular characterization of Klebsiella pneumoniae ST37 clinical isolates producing plasmid-mediated AmpC recovered over a 3-year period

Marina Illiaquer; Nathalie Caroff; Pascale Bémer; Guillaume G Aubin; Marie-Emmanuelle Juvin; Didier Lepelletier; Alain Reynaud; Stéphane Corvec

doi:10.1016/j.diagmicrobio.2012.05.023

Occurrence and molecular characterization of Klebsiella pneumoniae ST37 clinical isolates producing plasmid-mediated AmpC recovered over a 3-year period

Diagn Microbiol Infect Dis. 2012 Sep;74(1):95-7. doi: 10.1016/j.diagmicrobio.2012.05.023. Epub 2012 Jun 28.

Authors

Marina Illiaquer¹, Nathalie Caroff, Pascale Bémer, Guillaume G Aubin, Marie-Emmanuelle Juvin, Didier Lepelletier, Alain Reynaud, Stéphane Corvec

Affiliation

¹ Service de Bactériologie-Hygiène hospitalière, CHU Nantes, 9 quai Moncousu, 44093 Nantes Cedex 01, France.

PMID: 22749243
DOI: 10.1016/j.diagmicrobio.2012.05.023

Abstract

We investigated the clinical and microbiological epidemiology of AmpC plasmidic cephalosporinases (pAmpC) in Klebsiella pneumoniae strains resistant to ceftazidime, during a 3-year period (2007-2009). Among 1505 K. pneumoniae, 7 were pAmpC producers. Molecular characterization revealed the spread of a ST37 strain producing DHA-1 within intensive care units and the diffusion of the same plasmid among unrelated strains.

MeSH terms

Adult
Aged
Anti-Bacterial Agents / pharmacology
Bacterial Proteins / genetics*
Ceftazidime / pharmacology
Female
Humans
Klebsiella Infections / epidemiology*
Klebsiella pneumoniae / drug effects
Klebsiella pneumoniae / enzymology*
Klebsiella pneumoniae / genetics*
Klebsiella pneumoniae / isolation & purification
Male
Microbial Sensitivity Tests
Middle Aged
Molecular Epidemiology
Plasmids*
beta-Lactam Resistance
beta-Lactamases / genetics*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Ceftazidime
AmpC beta-lactamases
beta-Lactamases