Regulation of GPCR-mediated smooth muscle contraction: implications for asthma and pulmonary hypertension

D B Wright; S Tripathi; A Sikarwar; K T Santosh; J Perez-Zoghbi; O O Ojo; N Irechukwu; J P T Ward; D Schaafsma

doi:10.1016/j.pupt.2012.06.005

Regulation of GPCR-mediated smooth muscle contraction: implications for asthma and pulmonary hypertension

Pulm Pharmacol Ther. 2013 Feb;26(1):121-31. doi: 10.1016/j.pupt.2012.06.005. Epub 2012 Jun 27.

Authors

D B Wright¹, S Tripathi, A Sikarwar, K T Santosh, J Perez-Zoghbi, O O Ojo, N Irechukwu, J P T Ward, D Schaafsma

Affiliation

¹ Department of Asthma, Allergy, and Lung Biology, King's College, London, United Kingdom.

PMID: 22750270
DOI: 10.1016/j.pupt.2012.06.005

Abstract

Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca(2+)-mobilization and -sensitization.

Publication types

Review

MeSH terms

Animals
Asthma / physiopathology*
Calcium / metabolism
Humans
Hypertension, Pulmonary / physiopathology*
Muscle Contraction / physiology
Muscle, Smooth / metabolism
Muscle, Smooth, Vascular / metabolism
Receptors, G-Protein-Coupled / metabolism*

Substances

Receptors, G-Protein-Coupled
Calcium