Abstract
The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative approach for the development of cardiac therapeutics.
MeSH terms
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Cell Differentiation
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Cell Lineage
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Cell Transdifferentiation*
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Cellular Reprogramming*
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Fibroblasts / cytology*
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Fibroblasts / physiology
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Heart / physiology*
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Heart Failure / therapy*
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Humans
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MyoD Protein / biosynthesis
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Myocytes, Cardiac / cytology*
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Myocytes, Cardiac / physiology
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Regeneration
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Regenerative Medicine / methods
Substances
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MyoD Protein
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MyoD1 myogenic differentiation protein