Correlation between fecal concentrations of ciprofloxacin and fecal counts of resistant Enterobacteriaceae in piglets treated with ciprofloxacin: toward new means to control the spread of resistance?

Antimicrob Agents Chemother. 2012 Sep;56(9):4973-5. doi: 10.1128/AAC.06402-11. Epub 2012 Jul 2.

Abstract

We assessed in a piglet model the relationship between fecal ciprofloxacin concentrations and ciprofloxacin-resistant Enterobacteriaceae counts. Twenty-nine piglets were orally treated with placebo or with 1.5 or 15 mg ciprofloxacin/kg of body weight/day from day 1 (D1) to D5. Areas under the curve (AUC) of concentrations increased sharply with dose and correlated positively with AUC of resistant bacteria log counts between D1 and D9. Removing residual colonic quinolones could help to control the emergence of resistance in fecal flora.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / pharmacology
  • Area Under Curve
  • Bacterial Load
  • Ciprofloxacin / pharmacokinetics*
  • Ciprofloxacin / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Resistance, Bacterial / drug effects
  • Enterobacteriaceae / drug effects*
  • Enterobacteriaceae / growth & development
  • Feces / chemistry
  • Feces / microbiology*
  • Placebos
  • Swine

Substances

  • Anti-Bacterial Agents
  • Placebos
  • Ciprofloxacin