Abstract
High-throughput natural products chemistry methods have facilitated the isolation of eight new (1-8) and two known (9 and 10) beilschmiedic acid derivatives from the leaves of a Gabonese species of Beilschmiedia. Compounds 3-10 were isolated in microgram quantities, and the NMR data for structure elucidation and dereplication were acquired utilizing a Bruker BioSpin TCI 1.7 mm MicroCryoProbe. All of the compounds were screened for cytotoxic and antibacterial activity against NCI-H460 human lung cancer cells and a clinical isolate of methicillin-resistant Staphylococcus aureus, respectively. This is the first report of cytotoxic activity for the endiandric/beilschmiedic acid class of compounds.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / isolation & purification*
-
Anti-Bacterial Agents / pharmacology*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology*
-
Carboxylic Acids / chemistry
-
Carboxylic Acids / isolation & purification*
-
Carboxylic Acids / pharmacology*
-
Drug Screening Assays, Antitumor
-
Fatty Acids / chemistry
-
Fatty Acids / isolation & purification*
-
Fatty Acids / pharmacology*
-
Gabon
-
Humans
-
Lauraceae / chemistry*
-
Methicillin-Resistant Staphylococcus aureus / drug effects
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Leaves / chemistry
-
Staphylococcus aureus / drug effects
Substances
-
Anti-Bacterial Agents
-
Antineoplastic Agents
-
Carboxylic Acids
-
Fatty Acids
-
endiandric acid