Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure-activity relationships and in vivo study

J Antibiot (Tokyo). 2012 Sep;65(9):487-90. doi: 10.1038/ja.2012.51. Epub 2012 Jul 4.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemical synthesis*
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line, Tumor
  • Crohn Disease / drug therapy
  • Dose-Response Relationship, Drug
  • Humans
  • Immunologic Factors / chemical synthesis*
  • Immunologic Factors / chemistry
  • Immunologic Factors / pharmacology*
  • Macrolides / chemical synthesis*
  • Macrolides / chemistry
  • Macrolides / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents
  • Immunologic Factors
  • Macrolides