Reversible sudden hearing loss in a chronic hepatitis C patient who achieved a sustained response to antiviral re-treatment

Rosa Zampino; Giuseppe Costa; Mariarosaria Barillari; Luigi Elio Adinolfi; Aldo Marrone

Reversible sudden hearing loss in a chronic hepatitis C patient who achieved a sustained response to antiviral re-treatment

Infez Med. 2012 Jun;20(2):117-9.

Authors

Rosa Zampino¹, Giuseppe Costa, Mariarosaria Barillari, Luigi Elio Adinolfi, Aldo Marrone

Affiliation

¹ Department Internal Medicine and Hepatology, Second University of Naples, Naples, Italy.

PMID: 22767311

Abstract

We describe the case of a patient with chronic hepatitis C treated with standard and pegylated-interferon (PEG-IFN) alpha and ribavirin. He developed a reversible hearing loss during the first course of PEG-IFN + ribavirin, but achieved sustained viral clearance and biochemical normalization after PEG-IFN + ribavirin re-treatment.

Publication types

Case Reports

MeSH terms

Alanine Transaminase / blood
Anemia / etiology
Antiviral Agents / adverse effects*
Antiviral Agents / therapeutic use
Biomarkers
Drug Monitoring
Drug Substitution
Drug Therapy, Combination
Hearing Loss, Sudden / etiology*
Hearing Loss, Unilateral / etiology*
Hepatitis C, Chronic / blood
Hepatitis C, Chronic / complications*
Hepatitis C, Chronic / drug therapy
Humans
Interferon alpha-2
Interferon-alpha / adverse effects*
Interferon-alpha / therapeutic use
Male
Middle Aged
Polyethylene Glycols / adverse effects*
Polyethylene Glycols / therapeutic use
Recombinant Proteins / adverse effects
Recombinant Proteins / therapeutic use
Ribavirin / therapeutic use

Substances

Antiviral Agents
Biomarkers
Interferon alpha-2
Interferon-alpha
Recombinant Proteins
Polyethylene Glycols
Ribavirin
Alanine Transaminase
peginterferon alfa-2b