Abstract
The study is to investigate the effect of compound IMMLG5521, a coumarin derivative, on lung inflammation induced by Sephadex in rats. Sephadex led to massive granulomas, infiltration of neutrophils and eosinophils, the increase of TNF-α level in BALF and lung tissue. Sephadex injection led to the up-regulation of VCAM-1 and ICAM-1 expressions in the lungs. However, pretreatment with IMMLG5521 (6.25 and 12.5 mg/kg) inhibited massive granulomas and infiltration of neutrophils and eosinophils, decreased TNF-α level in BALF and lung tissue, and down-regulated VCAM-1 and ICAM-1 expressions in the lung tissue. In conclusion, compound IMMLG5521 may suppress the lung injury induced by Sephadex, at least in part, due to the prevention of the up-regulation of VCAM-1 and ICAM-1 expressions and TNF-α level.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Cell Movement / drug effects
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Coumarins / administration & dosage*
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Coumarins / chemistry
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Dextrans / administration & dosage
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Eosinophils / drug effects*
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Eosinophils / pathology
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Granuloma / chemically induced
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Granuloma / drug therapy*
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Granuloma / immunology
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Intercellular Adhesion Molecule-1 / metabolism
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Lung / drug effects*
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Lung / metabolism
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Lung / pathology
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Male
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Neutrophils / drug effects*
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Neutrophils / pathology
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Pneumonia / chemically induced
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Pneumonia / drug therapy*
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Pneumonia / immunology
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Rats
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Rats, Sprague-Dawley
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Tumor Necrosis Factor-alpha / metabolism
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Vascular Cell Adhesion Molecule-1 / metabolism
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Coumarins
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Dextrans
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IMMLG5521
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Tumor Necrosis Factor-alpha
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Vascular Cell Adhesion Molecule-1
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Intercellular Adhesion Molecule-1
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sephadex