Finding a druggable target for schizophrenia

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):11902-3. doi: 10.1073/pnas.1209389109. Epub 2012 Jul 9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Animals
  • Class I Phosphatidylinositol 3-Kinases
  • ErbB Receptors / metabolism*
  • Humans
  • Neuregulin-1 / metabolism*
  • Phosphoinositide-3 Kinase Inhibitors*
  • Quinazolines / pharmacology*
  • Receptor, ErbB-4
  • Schizophrenia / genetics*
  • Schizophrenia / metabolism*
  • Signal Transduction / physiology*

Substances

  • IC 87114
  • NRG1 protein, human
  • Neuregulin-1
  • Phosphoinositide-3 Kinase Inhibitors
  • Quinazolines
  • Class I Phosphatidylinositol 3-Kinases
  • PIK3CD protein, human
  • ERBB4 protein, human
  • ErbB Receptors
  • Receptor, ErbB-4
  • Adenine