New onset hypertensive disorders arising in the second half (>20 weeks) of pregnancy may persist beyond the puerperium. Using prospective follow-up data comprising information on 198 previously normotensive-non proteinuric women who developed hypertensive disorders after 20 weeks' gestation, we examined the prevalence and risk factors for persistence of hypertension after the puerperium. The prevalence of persistent hypertension was 25.8%. Compared with normotensive women, maternal age ≥35 years (OR = 14.89; 95% CI, 3.2-67.8), serum creatinine level (OR = 5.91; 95% CI,1.5-22.8), serum uric acid (OR = 37.49; 95% CI, 10.4-140.0) and maternal HIV infection (OR = 14.18; 95% CI, 1.5-132.0) were independently associated with persistent hypertension. Identification of women at risk of developing chronic hypertension after the puerperium can prevent morbidities related to hypertension.