The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS

T L Blundell; R Lapatto; A F Wilderspin; A M Hemmings; P M Hobart; D E Danley; P J Whittle

doi:10.1016/0968-0004(90)90280-o

The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS

Trends Biochem Sci. 1990 Nov;15(11):425-30. doi: 10.1016/0968-0004(90)90280-o.

Authors

T L Blundell¹, R Lapatto, A F Wilderspin, A M Hemmings, P M Hobart, D E Danley, P J Whittle

Affiliation

¹ Department of Crystallography, Birkbeck College, London, UK.

PMID: 2278102
DOI: 10.1016/0968-0004(90)90280-o

Abstract

A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acquired Immunodeficiency Syndrome / drug therapy*
Amino Acid Sequence
Animals
Antiviral Agents / chemistry*
Antiviral Agents / therapeutic use
Drug Design
HIV Protease / chemistry*
HIV Protease / genetics
Humans
Molecular Sequence Data
Pepsin A / genetics
Protease Inhibitors / chemistry
Protease Inhibitors / therapeutic use
Protein Conformation

Substances

Antiviral Agents
Protease Inhibitors
HIV Protease
Pepsin A