Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds

Chemistry. 2012 Aug 6;18(32):9901-10. doi: 10.1002/chem.201201039. Epub 2012 Jul 10.

Abstract

Despite their usefulness as fluorophores and synthetic precursors, efficient and reliable routes to coumarin-8-carbaldehydes are lacking. We describe here a high-yielding continuous flow synthesis that requires no manual intermediate purification or work-up, giving access to multigram quantities of the aldehyde product.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemical synthesis*
  • Aldehydes / chemistry*
  • Coumarins / chemical synthesis*
  • Coumarins / chemistry*
  • Fluorescent Dyes / chemistry*
  • Molecular Structure
  • Solid-Phase Synthesis Techniques / methods*

Substances

  • Aldehydes
  • Coumarins
  • Fluorescent Dyes