HLA-A and HLA-B gene polymorphism and idiopathic pulmonary fibrosis in a Han Chinese population

Idiopathic pulmonary fibrosis (IPF) is a progressive diffuse interstitial lung disease with poor prognosis of unknown etiology that leading ultimately to death. Predisposing factors are thought to have environmental and genetic inputs.

Objective: We investigated the relationship between HLA-A, B gene polymorphism and idiopathic pulmonary fibrosis (IPF) in a Han Chinese population.

Patients and methods: The gene frequency of 36 patients with IPF was detected using a PCR-SSP grouping method. These values were compared with those a Bone Marrow Bank (Shanghai, China) of healthy subjects of identical racial origin as the patient group.

Results: The gene frequency of HLA-A*3 (3.5%), HLA-B*14 (1.4%), -B*15 (10.2%), and -B*40 (5.0%)of the IPF group increased significantly (Pc < 0.05) compared with that in the control group HLA-A*3 (1.0%), HLA-B*14 (0.1%) and -B*15 (1.1%) and -B*40 (0.8%). Investigation of the link between the HLA-A and -B gene showed the gene frequency of HLA-A2B15 to be 5.0% as well as -A2B40 (4.3%), -A11B15 (5.0%), -A24B48 (2.8%) and -A30B40 (2.8%), which were significantly higher than those of the control group (Pc < 0.05).

Conclusion: These data suggest that the gene frequency of HLA-A*3, HLA-B*14, -B*15, -B*40, and the linked gene frequency of HLA-A2B15, -A2B40, -A11B15, -A24B58, -A30B40 is associated with IPF pathogenesis.