Abstract
From the ethanolic extract of Quercus glauca, two new lignans, (+)-5'-methoxyisolariciresinol-9'-O-α-L-rhamnopyranoside (1) and (7R,8S)-dihydrodehydrodiconiferyl alcohol 4-β-D-xyloside (2), along with fourteen known compounds including four lignanoids (3-6), five triterpenoids (7-11), two flavonoids (12, 13), two aromatics (14, 15), and one steroid (16) were isolated. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. Moreover, compounds 9 and 14 strongly inhibited nitric oxide (NO) production with IC<inf>50</inf> values of 8.25 and 14.04 µM, respectively, and compounds 1, 4-6, 14, and 15 showed moderate antioxidant activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Cell Line
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Ethanol / chemistry
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Lignans / chemistry*
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Lignans / isolation & purification
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Lignans / pharmacology
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Macrophages / drug effects
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Conformation
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Nitric Oxide / chemistry
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Nitric Oxide / metabolism
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Stems / chemistry
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Quercus / chemistry*
Substances
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(+)-5'-methoxyisolariciresinol-9'-O-alpha-L-rhamnopyranoside
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(7R,8S)-dihydrodehydrodiconiferyl alcohol 4-beta-D-xyloside
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Antioxidants
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Lignans
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Plant Extracts
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Nitric Oxide
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Ethanol