In vitro effects of pulmonary surfactant on macrophage morphology and function

L N Lepekha; E A Alexandrova; M V Erokhina

doi:10.1007/s10517-012-1560-8

In vitro effects of pulmonary surfactant on macrophage morphology and function

Bull Exp Biol Med. 2012 Feb;152(4):489-93. doi: 10.1007/s10517-012-1560-8.

[Article in English, Russian]

Authors

L N Lepekha¹, E A Alexandrova, M V Erokhina

Affiliation

¹ Institute of Tuberculosis, the Russian Academy of Medical Sciences, Moscow, Russia.

PMID: 22803118
DOI: 10.1007/s10517-012-1560-8

Abstract

The effects of pulmonary surfactant on the morphology and functioning of young macrophages were studied on the model of monocyte/macrophage differentiation in vitro and on macrophages of the bronchial alveolar lavage fluid. Surfactant is not a differentiation inductor, but it stimulated the maturation and phagocytic activity of young macrophages. The stimulatory effect of surfactant on phagocytic activity of macrophages persisted even after its removal from the culture medium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bronchoalveolar Lavage Fluid / cytology
Cell Differentiation / drug effects
Cell Line, Tumor
Humans
Macrophages, Alveolar / cytology
Macrophages, Alveolar / drug effects*
Monocyte-Macrophage Precursor Cells / cytology
Monocyte-Macrophage Precursor Cells / drug effects*
Monocytes / cytology
Monocytes / drug effects*
Phagocytosis / drug effects
Phorbol Esters
Pulmonary Surfactants / pharmacology*
Tuberculosis, Pulmonary / pathology

Substances

Phorbol Esters
Pulmonary Surfactants