Convulsive action of flunarizine in rabbits

Pol J Pharmacol Pharm. 1990 Jan-Feb;42(1):85-8.

Abstract

High doses of an anticonvulsant agent, flunarizine, given singly or repeatedly produce convulsions in rabbits. Albino rabbits were more vulnerable than mongrel ones. The flunarizine-induced convulsions are interrupted by diazepam.

MeSH terms

  • Animals
  • Convulsants*
  • Diazepam / pharmacology
  • Dose-Response Relationship, Drug
  • Female
  • Flunarizine / antagonists & inhibitors
  • Flunarizine / pharmacology*
  • Male
  • Rabbits
  • Stereotyped Behavior / drug effects

Substances

  • Convulsants
  • Diazepam
  • Flunarizine