HLA class I-mediated control of HIV-1 in the Japanese population, in which the protective HLA-B*57 and HLA-B*27 alleles are absent

J Virol. 2012 Oct;86(19):10870-2. doi: 10.1128/JVI.00689-12. Epub 2012 Jul 18.

Abstract

We investigated the effect of HLA class I alleles on clinical parameters for HIV-1 disease progression in the Japanese population, where two strongly protective alleles, HLA-B*57 and HLA-B*27, are virtually nonexistent. HLA-B alleles showed a dominant role, primarily through HLA-B*67:01 and the HLA-B*52:01-C*12:02 haplotype. Neither a rare-allele nor a heterozygote advantage was found, suggesting that the effect of HLA alleles in the Japanese population is either different from those observed in Africans and Caucasians or undetectable due to limited power.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Black People
  • CD4-Positive T-Lymphocytes / chemistry
  • Cohort Studies
  • Disease Progression
  • Epitopes / chemistry
  • Ethnicity
  • HIV Infections / immunology*
  • HIV Infections / prevention & control*
  • HLA Antigens / chemistry*
  • HLA Antigens / genetics
  • HLA-B Antigens / chemistry*
  • HLA-B Antigens / genetics*
  • HLA-B27 Antigen / chemistry*
  • HLA-B27 Antigen / genetics*
  • Heterozygote
  • Homozygote
  • Humans
  • Japan
  • Phenotype
  • Viral Load
  • White People

Substances

  • Epitopes
  • HLA Antigens
  • HLA-B Antigens
  • HLA-B27 Antigen
  • HLA-B57 antigen