The GAP between axon pruning and repulsion

Youngshik Choe; Samuel J Pleasure

doi:10.1016/j.devcel.2012.07.001

The GAP between axon pruning and repulsion

Dev Cell. 2012 Jul 17;23(1):3-4. doi: 10.1016/j.devcel.2012.07.001.

Authors

Youngshik Choe¹, Samuel J Pleasure

Affiliation

¹ Department of Neurology, Programs in Neuroscience, Developmental and Stem Cell Biology, Institute for Regeneration Medicine, University of California-San Francisco, CA 94158, USA.

Abstract

Stereotyped axonal pruning and growth cone repulsion, modulators of neuronal connectivity, share many ligands and receptors systems. Riccomagno et al. (2012) show in Cell that common ligands can link functionally specialized downstream pathways, demonstrating that the Rac GAP β2-Chimaerin is needed in Semaphorin-mediated axonal pruning but not growth cone repulsion.

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