Abstract
Adenovirus vector (Adv) vaccination at a systemic site, such as intramuscular (i.m.) immunization, can induce antigen-specific CD8(+) T cell responses in both systemic and mucosal compartments. It remains unclear, however, how antigen-specific CD8(+) T cell response is induced in the mucosa. In this study, we found that type-I IFN signaling is required for the induction of mRNA expression of retinal dehydrogenase in the draining lymph nodes following the i.m. Adv vaccination. We show that type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell response in the gut-mucosal compartment following the i.m. Adv vaccination.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism
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Adenovirus Vaccines / administration & dosage
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Adenovirus Vaccines / immunology*
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Animals
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CD8 Antigens / immunology*
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CD8-Positive T-Lymphocytes / immunology*
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Genetic Vectors / immunology
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Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
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Immunity, Innate
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Injections, Intramuscular
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Interferon Type I / metabolism*
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Intestinal Mucosa / immunology*
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Intestine, Small / immunology
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Lymph Nodes / immunology
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Mice
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Mice, Inbred C57BL
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Mice, Mutant Strains
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Receptor, Interferon alpha-beta / genetics
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Receptor, Interferon alpha-beta / metabolism
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Signal Transduction
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Tretinoin / metabolism
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Vaccination
Substances
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Adaptor Proteins, Signal Transducing
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Adenovirus Vaccines
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CD8 Antigens
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IPS-1 protein, mouse
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Ifnar2 protein, mouse
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Interferon Type I
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Receptor, Interferon alpha-beta
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Tretinoin
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Granulocyte-Macrophage Colony-Stimulating Factor