Abstract
With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (1), a potent natural α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, have been developed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Drug Design
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Glycoside Hydrolase Inhibitors*
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Humans
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / pharmacology
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Models, Molecular
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Rats
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Salacia / chemistry*
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Structure-Activity Relationship
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Sugar Alcohols / chemistry*
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Sugar Alcohols / isolation & purification
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Sugar Alcohols / pharmacology*
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Sulfates / chemistry*
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Sulfates / isolation & purification
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Sulfates / pharmacology*
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alpha-Glucosidases / chemistry
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alpha-Glucosidases / metabolism
Substances
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Enzyme Inhibitors
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Glycoside Hydrolase Inhibitors
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Hypoglycemic Agents
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Plant Extracts
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Sugar Alcohols
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Sulfates
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salacinol
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alpha-Glucosidases