Abstract
The synthesis of 5-methyl-10,11-dihydro-5H-pyrrolo [1,2-b] [1,2,5]benzotriazepine-11-acetic acid and its 10-aroyl derivatives is reported. Compounds were evaluated for antiinflammatory activity by the carrageenin-induced rat paw edema method. Antinociceptic activity was tested by the hot plate and Randall-Selitto tests. General neuropsychopharmacological effects were also screened. All test compounds showed antiinflammatory effect comparable to that of tolmetin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemical synthesis
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anticonvulsants / chemical synthesis
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Benzazepines / chemical synthesis*
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Benzazepines / chemistry
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Benzazepines / pharmacology
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Exploratory Behavior / drug effects
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Female
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Male
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Mice
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Motor Activity / drug effects
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Muscle Relaxants, Central / chemical synthesis
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Pain Measurement
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Psychomotor Performance / drug effects
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Pyrroles / chemical synthesis*
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Pyrroles / chemistry
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Pyrroles / pharmacology
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Rats
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Rats, Inbred Strains
Substances
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Analgesics
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Anti-Inflammatory Agents, Non-Steroidal
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Anticonvulsants
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Benzazepines
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Muscle Relaxants, Central
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Pyrroles
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5-methyl-10,11-dihydro-5H-pyrrolo(1,2-b)(1,2,5)benzotriazepine-11-acetic acid