Two-stage meta-analysis of survival data from individual participants using percentile ratios

Stat Med. 2012 Dec 30;31(30):4296-308. doi: 10.1002/sim.5516. Epub 2012 Jul 24.

Abstract

Methods for individual participant data meta-analysis of survival outcomes commonly focus on the hazard ratio as a measure of treatment effect. Recently, Siannis et al. (2010, Statistics in Medicine 29:3030-3045) proposed the use of percentile ratios as an alternative to hazard ratios. We describe a novel two-stage method for the meta-analysis of percentile ratios that avoids distributional assumptions at the study level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Computer Simulation
  • Glioma / surgery
  • Humans
  • Kaplan-Meier Estimate
  • Logistic Models
  • Meta-Analysis as Topic*
  • Odds Ratio
  • Postoperative Care / methods
  • Postoperative Care / statistics & numerical data
  • Probability
  • Proportional Hazards Models
  • Survival Analysis*
  • Treatment Outcome*