Identification of two novel HLA-A alleles: A*24:199 and A*02:324

Int J Immunogenet. 2013 Apr;40(2):151-3. doi: 10.1111/j.1744-313X.2012.01144.x. Epub 2012 Jul 26.

Abstract

Here, we describe two new HLA-A alleles: A*24:199 and A*02:324. The two new variants are attributed to a single nucleotide mutation namely A→C for A*24:199 and G→A for A*02:324. Both point mutations are responsible for a change in translated amino acids.

MeSH terms

  • Alleles
  • Base Sequence
  • HLA-A2 Antigen / genetics*
  • HLA-A24 Antigen / genetics*
  • Histocompatibility Testing
  • Humans
  • Molecular Sequence Data
  • Point Mutation
  • Polymorphism, Single Nucleotide
  • Sequence Analysis, DNA

Substances

  • HLA-A*02 antigen
  • HLA-A2 Antigen
  • HLA-A24 Antigen